Clostebol acetate
نویسندگان
چکیده
The title compound, C(21)H(29)ClO(3) [systematic name (8R,9S,10R,13S,14S,17S)-4-chloro-3-oxoandrost-4-en-17β-yl acetate], is a 4-chloro derivative of testosterone, used as an anabolic androgenic agent or applied topically in ophthalmological and dermatological treatments. The absolute configurations at positions 8, 9, 10, 13, 14 and 17 were established by refinement of the Flack parameter as R, S, R, S, S, and S, respectively. Rings B and C of the steroid ring system adopt chair conformations, ring A has a half-chair conformation, while ring D is in a C(13) envelope conformation. Ring B and C, and C and D are trans fused. In the crystal, molecules are linked by a weak C-H⋯O interaction.
منابع مشابه
Clostebol-positive urine after consumption of contaminated meat.
We examined the relationship between the consumption of meat from animals treated with anabolic steroids and the detection of these steroids in the athletes consuming this meat. We proved that clostebol metabolites (e.g., 4-chloro-delta-4-androstene-3 alpha-ol-17-one) in the urine of one of the volunteers involved in a feeding experiment were due to accidental consumption of meat contaminated w...
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To the Editor: Clostebol is a synthetic androgenic steroid with anabolic effects that is frequently used in sports to increase physical performance. Because of medical and ethical reasons, the use of clostebol is prohibited by the International Olympic Committee (IOC) (1 ), and its misuse would fall under the strict liability rule of the IOC and the World Antidoping Agency. It is therefore the ...
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Clostebol acetate (4-chloro-testosterone acetate) is an anabolic steroid used for fattening purposes in cattle breeding. To safeguard public health, its use has been prohibited by the European Commission since 1986. Screening for its urinary metabolites is therefore an important tool for the control of possible violations. Because those metabolites appear conjugated to glucuronic acid or sulfat...
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Anabolic androgenic steroids (AAS) are synthetic testosterone derivatives which undergo extensive metabolism in man. Differences in the excretion of phase II metabolites are strongly associated with inter-individual and inter-ethnic variations. Sulfate metabolites have been described as long-term metabolites for some AAS. Clostebol is the 4-chloro derivative of testosterone and the aim of the p...
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